通用名称
atezolizumab英文名称
Atezolizumab汉语拼音
N/A药品类型
intravenous (infusion) injection处方类型
N/A医保类型
N/A- What is atezolizumab?
- Important information
- What should I tell my doctor before receiving atezolizumab?
- How should I receive atezolizumab?
- What happens if I miss a dose?
- Dosing information
- What are the side effects of atezolizumab?
- Interactions
- Pregnancy and breastfeeding
- Storage
- What are the ingredients in atezolizumab?
- Popular FAQ
-
What is atezolizumab?
Atezolizumab is a type of immunotherapy drug that helps the body's immune system to track down and fight cancer. It is a monoclonal antibody that works by blocking a protein called programmed death-ligand 1 (PD-L1). It is part of a group of drugs called immune checkpoint inhibitors, which help to extend the amount of time a person can live with cancer or life without their cancer getting worse.@@@@@@Atezolizumab. was first approved by the US Food and Drug Administration (FDA) in 2016.@@@
-
Important information
Atezolizumab is a medicine that may treat certain cancers by working with your immune system. Atezolizumab can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during your treatment or even after your treatment has ended.@@@Call or see your healthcare provider right away if you develop any new or worse signs or symptoms, including:@@@Lung problems. cough shortness of breath chest pain Intestinal problems. diarrhea (loose stools) or more frequent bowel movements than usual stools that are black, tarry, sticky, or have blood or mucus severe stomach-area (abdomen) pain or tenderness Liver problems. yellowing of your skin or the whites of your eyes severe nausea or vomiting pain on the right side of your stomach area (abdomen) dark urine (tea colored) bleeding or bruising more easily than normal Hormone gland problems. headaches that will not go away or unusual headaches eye sensitivity to light eye problems rapid heart beat increased sweating extreme tiredness weight gain or weight loss feeling more hungry or thirsty than usual urinating more often than usual hair loss feeling cold constipation your voice gets deeper dizziness or fainting changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness Kidney problems. decrease in your amount of urine blood in your urine swelling of your ankles loss of appetite Skin problems. rash itching skin blistering or peeling painful sores or ulcers in mouth or nose, throat, or genital area fever or flu-like symptoms swollen lymph nodes Problems can also happen in other organs. These are not all of the signs and symptoms of immune system problems that can happen with atezolizumab. Call or see your healthcare provider right away for any new or worse signs or symptoms, including: chest pain, irregular heartbeat, shortness of breath, or swelling of ankles confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs double vision, blurry vision, sensitivity to light, eye pain, changes in eye sight persistent or severe muscle pain or weakness, muscle cramps low red blood cells, bruising Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include: chills or shaking itching or rash flushing shortness of breath or wheezing dizziness feeling like passing out fever back or neck pain Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with atezolizumab. Your healthcare provider will monitor you for these complications.@@@@@@Getting medical treatment right away may help keep these problems from becoming more serious.@@@Your healthcare provider will check you for these problems during your treatment with atezolizumab. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with atezolizumab if you have severe side effects.@@@
-
What should I tell my doctor before receiving atezolizumab?
Before receiving atezolizumab, tell your healthcare provider about all of your medical conditions, including if you:@@@have immune system problems such as Crohn's disease, ulcerative colitis, or lupus have received an organ transplant have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic) have received radiation treatment to your chest area have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome@@@Atezolizumab pregnancy and breastfeeding warnings (more detail)@@@
-
How should I receive atezolizumab?
Your healthcare provider will give you atezolizumab into your vein through an intravenous (IV) line over 30 to 60 minutes. Atezolizumab is usually given every 2, 3, or 4 weeks. Your healthcare provider will decide how many treatments you need. Your healthcare provider will test your blood to check you for certain side effects. For treatment of a type of skin cancer called melanoma, your healthcare provider will also prescribe you cobimetinib and vemurafenib. Take cobimetinib and vemurafenib exactly as your healthcare provider tells you.@@@
-
What happens if I miss a dose?
If you miss any appointments, call your healthcare provider as soon as possible to reschedule your appointment.@@@
-
Dosing information
Urothelial Carcinoma. Administer atezolizumab as a single agent as 840 mg every 2 weeks, 1200 mg every 3 weeks, or 1680 mg every 4 weeks. NSCLC. In the adjuvant setting, administer atezolizumab following resection and up to 4 cycles of platinum-based chemotherapy as 840 mg every 2 weeks, 1200 mg every 3 weeks or 1680 mg every 4 weeks for up to 1 year. In the metastatic setting, administer atezolizumab as 840 mg every 2 weeks, 1200 mg every 3 weeks, or 1680 mg every 4 weeks. When administering with chemotherapy with or without bevacizumab, administer atezolizumab prior to chemotherapy and bevacizumab when given on the same day. Small Cell Lung Cancer. Administer atezolizumab as 840 mg every 2 weeks, 1200 mg every 3 weeks, or 1680 mg every 4 weeks. When administering with carboplatin and etoposide, administer atezolizumab prior to chemotherapy when given on the same day. Hepatocellular Carcinoma. Administer atezolizumab as 840 mg every 2 weeks, 1200 mg every 3 weeks, or 1680 mg every 4 weeks. Administer TECENTRIQ prior to bevacizumab when given on the same day. Bevacizumab is administered at 15 mg/kg every 3 weeks. Melanoma. Following completion of a 28 day cycle of cobimetinib and vemurafenib, administer atezolizumab 840 mg every 2 weeks, 1200 mg every 3 weeks, or 1680 mg every 4 weeks with cobimetinib 60 mg orally once daily (21 days on /7 days off) and vemurafenib 720 mg orally twice daily.@@@Detailed Atezolizumab dosage information@@@@@@
-
What are the side effects of atezolizumab?
Atezolizumab can cause serious side effects, including:@@@See "Important information" above.@@@The most common side effects of atezolizumab when used alone include:@@@feeling tired or weak decreased appetite nausea cough shortness of breath@@@The most common side effects of atezolizumab when used in lung cancer with other anti-cancer medicines include:@@@feeling tired or weak nausea hair loss constipation diarrhea decreased appetite@@@The most common side effects of atezolizumab when used in hepatocellular carcinoma with bevacizumab include:@@@high blood pressure feeling tired or weak too much protein in the urine@@@The most common side effects of atezolizumab when used in melanoma with cobimetinib and vemurafenib include:@@@skin rash joint, muscle, or bone pain feeling tired or weak liver injury fever nausea itching swelling of legs or arms mouth swelling (sometimes with sores) low thyroid hormone levels sunburn or sun sensitivity@@@Atezolizumab may cause fertility problems in females, which may affect the ability to have children. Talk to your healthcare provider if you have concerns about fertility.@@@These are not all the possible side effects of atezolizumab.@@@Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.@@@Atezolizumab side effects (more detail)@@@
-
Interactions
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.@@@Atezolizumab drug interactions (more detail)@@@@@@
-
Pregnancy and breastfeeding
Tell your doctor if you are pregnant or plan to become pregnant. atezolizumab can harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with atezolizumab.@@@Females who are able to become pregnant:@@@Your healthcare provider should do a pregnancy test before you start treatment with atezolizumab. You should use an effective method of birth control during your treatment and for at least 5 months after the last dose of atezolizumab.@@@Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if atezolizumab passes into your breast milk. Do not breastfeed during treatment and for at least 5 months after the last dose of atezolizumab.@@@
-
Storage
Store atezolizumab vials under refrigeration at 2°C to 8°C (36°F to 46°F) in original carton to protect from light. Do not freeze. Do not shake.@@@
-
What are the ingredients in atezolizumab?
Active ingredient: atezolizumab@@@Inactive ingredients: glacial acetic acid, L-histidine, polysorbate 20 and sucrose@@@Atezolizumab is manufactured by Genentech, Inc., a member of the Roche Group, 1 DNA Way, South San Francisco, CA 94080-4990 USA, under the brandname Tecentiq.@@@
-
Popular FAQ
Are there cost-saving programs for Tecentriq? Is this a chemotherapy or immunotherapy drug? How effective is it? Does it cause hair loss? How is it administered? What type of cancer is Tecentriq used to treat?@@@View more FAQ@@@References National Library of Medicine Tecentriq Product Label Aleem A, Shah H. Atezolizumab. [Updated 2022 Jan 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-.@@@More about atezolizumab Check interactions Compare alternatives Reviews (6) Latest FDA alerts (2) Side effects Dosage information During pregnancy Drug class: anti-PD-1 and PD-L1 monoclonal antibodies (immune checkpoint inhibitors) Breastfeeding En español Patient resources Other brands Tecentriq Professional resources Atezolizumab monograph Other brands Tecentriq Related treatment guides Alveolar Soft Part Sarcoma Bladder Cancer Breast Cancer Hepatocellular Carcinoma@@@